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Latest Insights


What is Urolithin A?
Urolithin A: The Mitochondrial Reset Your Muscles Have Been Waiting For Oct 11, 2026 · Urolithin A is a gut-derived compound that helps your cells clear out worn-out mitochondria, and randomized human trials now link it to better muscle strength, endurance, and immune markers in adults over 40. If you train hard, eat well, and still feel like recovery is slower than it was at 30, the bottleneck may not be your effort. It may be the quality of the energy factories inside your
David Cesarino, PA-C, MPAS
Oct 116 min read


DIM and Estrogen Metabolism on TRT
At Alpha Performance Clinic, we focus on optimizing hormones for performance, recovery, and long-term health—not just hitting a single lab number. One area that often gets overlooked in testosterone replacement therapy (TRT) is how the body processes estradiol, not only the total estradiol (E2) level. This is where DIM (diindolylmethane) comes in. What Is DIM? DIM is a natural compound formed when the body digests indole-3-carbinol, a substance found in cruciferous vegetables
David Cesarino, PA-C, MPAS
Aug 83 min read


The FDA Just Rewrote the Rules on Testosterone.
If you've been on the fence about testosterone replacement therapy (TRT) — or you've heard secondhand warnings about heart attacks and prostate cancer that made you hesitate — the conversation just changed. On June 18, 2026, the U.S. Department of Health and Human Services and the FDA announced a major request to update the prescribing labels on every testosterone replacement product on the market. This isn't a minor footnote. It's the most significant shift in TRT regulation
David Cesarino, PA-C, MPAS
Jun 225 min read
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